Diabetes

Here we show a selected set of resources for understanding diabetes mellitus, arranged to follow a curriculum. It isn’t a comprehensive set, it is our choices, ranging from introductory to specialist level.

There are many valuable resources for diabetes, but also some gaps. Please let us know if you would like to recommend something.

Overview

In Diabetes Mellitus blood glucose is high because the glucose-lowering hormone Insulin is either under-produced, or its effect is blunted by insulin resistance. Under-production is the main problem in Type 1 diabetes, and insulin resistance is a major problem in type 2 diabetes, but this can be an oversimplification, and some patients have combined or different problems.

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    Level ALevel B

    WHO General Diabetes Info

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    The WHO has created pages for most global disease. This page gives some general information about diabetes, features some case examples, links to concesus documents and offers some facts and figures.
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    Level ALevel B

    Open University – Living with Diabetes

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    This high quality interactive module introduces the parts of the body and processes involved in the development of diabetes. A good overview of the physiology of diabetes. Useful for health professionals (nurses, medical students, junior doctors) and motivated patients. There are scattered clinical scenarios throughout. These module take a few hours to complete, but worth setting aside the time

Pathophysiology

Diabetes mellitus is the generic term for a group of disorders, all of which share the common feature of an uncontrolled elevation of blood glucose (hyperglycaemia).킠 Hyperglycaemia may result from a lack of the anabolic hormone, insulin, (as in Type 1 Diabetes) or a reduction of its action (as in Type 2 Diabetes) and may be associated with other disorders such as pancreatic or liver disease.

Hyperglycaemia is only one manifestation of the abnormal metabolism inherent in diabetes.킠킠 In humans, insulin plays a central role in cell metabolism and modulates carbohydrate, fat and protein metabolism, so its absence or dysfunction has a profound effect on most tissues and organs. Immunological concepts of autoimmune disease are considered in the pathogenesis of type 1 (insulin dependent) diabetes. The more chronic pathological changes of tissue glycation leading to vascular complications is cover in part here, but mainly in later sections.

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    Level BLevel C

    Tufts OCW Lecture Notes

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    TUFTSs university have given open access to the lecture notes that complement their course on the Pathophysiology of Endocrinology, Diabetes and Metabolism- click on í¢’‚¬Ëœlecturesí¢’‚¬’„¢. The resources also contains case based tutorials, and answers. Covers all diabetes and all endocrinology major sub-specialities... read more

Classification of Diabetes

Diabetes is crudely divided into type 1 diabetes (an autoimmune disease predominantly affecting young people), and type 2 diabetes, which is often associated with insulin resistance and obesity. Emerging monogenic forms of diabetes, and latent onset autoimmune disease however challenge these traditional categorizations. The WHO documentation (below) tackles the issues of diabetes diagnosis and classification in the modern era.

Diagnosis of diabetes and laboratory tests

Diabetes diagnosis currently rests on testing for raised fasting plasma glucose or raised plasma glucose following oral glucose tolerance testing, although there may be a move towards using HbA1C for diagnosis. The WHO publication (below) discusses the current methods for diagnosing diabetes. Making the individual diagnosis and initiating treatment in the clinic is covered in the case scenarios.

Patient Self Management and Lifestyle

Patient education is crucial to tackle lifestyle factors and allow patients to manage their diabetes effectively, and understand the impact of diet, alcohol and exercise. These resources demonstrate the impact of lifestyle through clinical scenarios/ interactive modules and point to resources to help with patient education.

Obesity and the Metabolic Syndrome

Obesity is associated with many metabolic consequences, including hypertension, dyslipidaemia, insulin resistance or frank diabetes. Lifestyle modification is key to the management of type 2 diabetes. Clinicians need to understand the pathophysiology of obesity, and consider therapeutic measures to induce weight loss where appropriate.

Diabetes킠 Complications

Severe insulin deficiency may provoke an acute metabolic crisis, such as life-threatening ketoacidosis. Other acute complications of diabetes include severe hypoglycaemia, HONK and lactic acidosis.
The biggest long-term problem associated with diabetes is the greatly increased risk of developing vascular disease.킠킠 This affects both small blood vessels in the form of microvascular disease, which targets and damages organs such as the eyes, kidneys and peripheral nerves.킠 It also promotes the premature development of atherosclerosis, the common disease of large blood vessels, which results in heart attacks, strokes and ischaemia of the lower limbs (sometimes necessitating amputation).킠킠 Diabetes is therefore a systemic disease with complications affecting most systems of the body and having widespread manifestations leading to major morbidity and reduced life expectancy. There are lots of resources in this area.

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    Level ALevel B

    Open University – Diabetes Complications

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    This high quality interactive module looks at the way diabetes is managed once it has been diagnosed in order to reduce the risk of further complications. It is useful for junior doctors though to newly diagnosed patients. It focues on patient based scenarios to look at a modern healthcare systems and procedures to manage diabetes and its complications.
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    Level ALevel BLevel C

    Diabetic Foot Video

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    Video about diabetic Neuropathy and how to screen a diabetic foot. Good for anyone dealing with diabetes patients, from GPs to foot screeners to specialst doctors. Could also be used for patient education.
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    Level ALevel B

    Mydiabetesmyway

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    The Scotttish Patient Portal site - written for patients but contains loads of interactive resources, patient testimonies and downloadable fact sheets that will be useful for health professionals too. The categorisation of resources into diabetes mind/ body etc. is a bit confusing. Also it would nice if the resources were rated and a bit more descr... read more

Diabetes and Pregnancy

Traditionally, most women with diabetes who become pregnant had Type 1 diabetes (insulin-dependent diabetes), however increasing numbers of pregnant women with Type 2 diabetes (non-insulin dependent diabetes), and gestational diabetes are now being treated. Diabetes in pregnancy poses a number of risks to mother and baby: babies born to mothers with poor blood sugar control are more likely to have birth defects or be stillborn and babies born to mothers with diabetes weigh more than average, especially if glucose control has been poor.

For the mother, diabetes and pregnancy can be associated with extra risks. Retinopathy may increase in severity, and diabetic kidney disease increases the chance of developing high blood pressure and a more serious condition called pre-eclampsia that can affect mother and baby.
Good glucose control well before conceiving and throughout pregnancy reduces the chance of all these problems occurring. Insulin treatment was the mainstay of diabetes management in pregnancy although there is growing evidence that metformin may be safe during pregnancy and preferable as a first line agent in patients with type 2 diabetes.킠 More and better teaching resources are required in this specialist area.

Pharmacotherapies

There are many medications already available for the treatment of diabetes and a huge number of new drugs currently going through clinical trials.
Insulin remains the mainstay of treatment for type 1 diabetes, although new insulin preparations and pump administration are widening the therapeutic options.
In type 2 diabetes most current drugs work by either increasing insulin secretion by the pancreas, improving tissue sensitivity to circulating insulin or altering carbohydrate digestion and absorption in the gut.킠 Insulin therapy may ultimately be required for type 2 patients if pancreatic reserve fails.

 

 

 

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